Worth knowing · Your medication may be using this up
What happens
Metformin can lower your B12 over time. Low B12 shows up as tiredness, tingling in your hands or feet, or brain fog. These are all easy to blame on PCOS itself.
What to do
Ask for a B12 level at your next blood draw, and supplement if it comes back low. If you've been on metformin four years or more, ask for it yearly.
Source: FDA metformin prescribing information; NIH Office of Dietary Supplements, Vitamin B12
Last reviewed: July 2026
